Thursday , June 17 2021

Biliary infection may be associated with Alzheimer's disease: Study



Alzheimer's disease

Biliary infection may be associated with Alzheimer's disease: Study & nbsp | & nbspPhoto Credit: & nbspThinkstock

Washington: A new study, published in the journal Science Advances, found that gum infection can be a potential risk factor for Alzheimer's disease. Bacteria, Porphyromonas gingivalis, known as Pg, cause chronic periodontitis of gum infection, causing chronic inflammation and potential tooth loss, reported CNN.

The same bacteria were detected in 51 of 53 cerebral autopsies in patients with Alzheimer's disease, according to a new study by Dr. Stephen Dominini and Casey Lynch, founders of the Cortexyme pharmaceutical company. The pharmaceutical company, which focuses on the development of therapeutic tools for altering the course of Alzheimer's disease, finances the study.

The team also investigates the blocking of bacteria in mice by injecting small molecules directed against Pg to inhibit it and found that it can reduce neurodegeneration in the brain, indicating a potential new way to deal with Alzheimer's disease.

According to Lynch, her team's publication "sheds light on the unexpected driver of Alzheimer's pathology, the bacterium often associated with chronic gum disease." Lynch adds that he also shows a "promising approach" to tackle the disease.

In addition, Lynch adds that while previous studies have established a link between periodontal disease and Alzheimer's disease, the new study notes a "very significant" link between Alzheimer's disease and oral infection, and that the study of mice shows a causal relationship.

Alzheimer's disease is the most common form of dementia, characterized by memory loss, which increases over time. It is believed to be caused by the accumulation of beta amyloid plaques and neurofibrillary connections called tau in the brain. There is no cure for the disease yet.


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