Thursday , July 29 2021

Scientists determine the underlying cause of Alzheimer's disease



The study of the causes of Alzheimer's disease can be turned upside down after a group of scientists conducted a rodent study and from the center of the stage to the amyloid precursor protein (APP), linking the origin. of the disease by its cholesterol interaction in the synapses' membranes.


So far, it has been known that the mutations suffered by APP are related hereditary forms of the diseasealthough treatments based on this protein do not produce the expected results.

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That's why a team at the Atlanta University Brain Institute in Florida (USA) placed fluorescent "markers" in APP to be able to track and analyze them behavior in rat tissue, So they found curious Interaction between proteins and cholesterol molecules which affect the membrane in the neural connections.

So they explained that in the most common type of Alzheimer's, the highest risk factor is not APP, a proteins that transport cholesterol, published neurobiology of diseases. This new security is also based on the failure of treatments that indicate APP.

brain

Previous research

Several investigations have already been carried out on this issue, such as that led by Tsi Zhang of the Brain Institute, along with associates from the University of Vanderbilt, Tennessee (USA), which consists of interruption of the relationship between APP and cholesterolThey found that this stopped the movement of APP and confused the distribution of cholesterol on the neuronal surface.

Thus, neurons undergo changes in synapse, fragmentation of axons, and other early signs of neurodegeneration.

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– Our research is interesting because we noticed a special relationship between APP and cholesterol which is in the cell membrane of synapses that are points of contact between neurons and the biological basis of learning and memory, Zhang explained.

APP may be one of the many contributors who contribute partially to cholesterol deficiency. Interestingly, that heart and brain meet again in the fight against bad cholesterolHe concluded.

However, it has not yet been proven that reducing cholesterol through diet, can be a useful factor in the fight against Alzheimer's disease,


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