For some time, scientists believe that dementia of Alzheimer's disease can be an infectious disease. Still, researchers have failed to understand the exact processes of such an infection. However, a new study has found the clearest indication to date that there is actually a link between Alzheimer's disease and bacterial infection.
Researchers led by microbiologist Ian Potempa of the University of Louisiana, Louisville, discovered the bacterium Porphyromonas gingivalis, which is responsible for dental and gingival diseases in the brains of the deceased Alzheimer's patients.
Subsequently, researchers found in mice experiments that mouth infection actually resulted in colonization of bacteria in the brain. In the brain, they cause increased production of the antibacterial beta-amyloid protein whose deposits are associated with Alzheimer's disease.
Developed active ingredient
At the same time, researchers discovered in the brain gingipain. These are toxic enzymes formed by bacteria. They also found them in the brain of the deceased who had never been diagnosed with Alzheimer's disease. Alzheimer may have exploded with them if they lived longer. Researchers value this as a sign that Alzheimer's does not cause tooth and gum disease, but vice versa.
As part of the study, Cortexyme, a pharmaceutical start involved in the study, developed a compound called COR388 that reduces the bacterial count of brain infection with Porphyromonas gingivalis as well as the production of beta-amyloid in a mouse experiment. However, according to the researchers, it is still not possible to confirm the effectiveness of COR388 in the fight against Alzheimer's disease.