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Supersaturated intestinal bacteria remove our intestinal flora from equilibrium



Relationship between modern food and civilization diseases

Are we getting sick? Kiel's research team uses a new hypothesis, all the modern food that is involved. Researchers blame the continued excess supply of food for many chronic inflammatory bowel diseases that have grown since the end of World War II. According to their hypothesis, intestinal bacteria by overeating remove their initial tasks and thus promote the development of diseases.

All animals and plants are colonized by microorganisms that perform multiple tasks in the body. Interactions of microbes are becoming clearer through current research. It has long been clear that microbial plays a crucial role in human health. Joint Research Center 1182 at Christian-Albrechts-Universität Kiel explores the appearance and functioning of meta-organisms. In a recent study, presented in "mBio", researchers have established a link between modern nutrition and the development of various chronic inflammatory bowel diseases, such as Crohn's disease or ulcerative colitis.

Continued food supply, according to a recent study, is responsible for more and more people suffering from inflammation of the gut. (Image: contrastwerkstatt / fotolia.com)

Feeding in the intestine

Inflammatory diseases are caused by overload with food and the associated disorder of natural bacterial colonization of the gut. This is the hypothesis of Kiel's research team. People have changed their diet over the last decades in an unbalanced, high-energy and low-fiber way that offers a consistently high, yet easy to use, nutrient supply. According to the Joint Research Center (SFB) 1182, this means that some intestinal bacteria no longer feed on metabolites (metabolites), but directly benefit from excess nutrients. As a result, intestinal bacteria are secreted from the host. No more interactions and the original task of the organisms is eliminated.

What are the consequences of such separation?

"This bacterial overgrowth stimulates their overall growth, the growth of some bacterial species to the detriment of other members of the microbiome, fortified and uncontrolled," sums up Professor Thomas Bosch of SFB 1182 in a press release. This changes the composition of bacterial colonization and the interactions between the bacteria and the host organism. This can lead to serious disorders of the gut flora and cause so-called dysbiosis, i. E. harmful imbalance in the gut microbe.

The microbial influence causes people to get sick

Other research approaches have already shown equally fatal consequences if the human microbial is adversely affected. Earlier studies have shown that excessive hygiene and the intensive use of antibiotics permanently disturb the microbe and make people more susceptible to disease. Recent findings have made it increasingly clear that micro-organisms play a crucial role in human and animal health. For more information read the article: Not only antibiotics – every fourth drug destroys our intestinal flora.

The origin is at sea

The starting point of the hypothesis is the current study of the coral. The Kiel research group showed how bacteria are released from corals when nutrient conditions in seawater are rising. The coral microbial is out of balance due to migration. The result: Corals get sick. "In this connection between the presence of nutrients and the balance of the host-bacterial relationship, we see a universal principle that far exceeds the very specific example of coral," says the first author of the study. Tim Lachen. In further model experiments, the team is also able to confirm this coupling in freshwater polyps. The researchers conclude that "the insights gained in the experiment are likely to be transferred to human health as well."

Can a damaged intestinal flora be cured?

So far, medicine has been attempting to treat a disturbed microbe, for example, by administering probiotics or faecal transplants. The new hypothesis now opens new approaches to research and therapies. Now we need to find out if the microbe can adjust again and restore health through a certain diet.

Researchers see potential in the fasting

Kiel's research team now wants to explore the therapeutic potential of this hypothesis in further research. Since bacteria are literally overproduced, researchers see a therapeutic potential for starvation. "In the future, for example, in addition to the well-known health effects of fasting, we will also look at its effects on the composition and function of the microbe and thus on the course of inflammatory diseases," Lakhnit said. (Vb)


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