Posted Friday, January 25, 2019 7:56 EST
Last Updated Friday, 25 January, 2019 8:10 EST
Thin people find it easier to maintain a healthy weight in part because of their genes according to new research.
In the largest study of this type so far, researchers from the UK have found that thin people have an advantage when it comes to staying thin due to their genes.
Interestingly, some people find it easier to remain weak than others, researchers at Cambridge University, along with Wellcome's support and the European Research Council, have developed a STILTS study for healthy adults in the UK at age 18 years to 65, which are thin – defined as a body mass index (BMI) of less than 18 kg / m2 – and without medical conditions or eating disorders.
Participants were asked to provide saliva samples for DNA analysis and to answer questions about their general health and lifestyle.
The team then worked with the Wellcome Sanger Institute to compare DNA from a total of 14,000 adults, including 1,622 thin volunteers from the STILTS study, 1985 heavy obese people and 10,443 normal weight controls.
The findings, published in the journal PLOS Genetics, showed that 74% of people in the STILTS group had a family history of being weak and healthy.
In addition to finding genetic variants that have already been identified as playing a role in obesity, researchers have also discovered new genetic regions involved in severe obesity and healthy subtlety.
To understand how these genes affect body weight, scientists add the contribution of the various genetic variants to calculate genetic risk.
The results show that thin people have a much lower genetic risk, which means they have fewer genetic variants known to increase the chances of a person being overweight.
"As we expected, we found that obese people have a higher genetic risk than normal people, contributing to the risk of overweight." Genetic dice are loaded against them, "said Dr. Ines Barroso of the Wellcome Sanger Institute.
"This study shows for the first time that healthy thin people are usually thin, because they have a lower weight of genes that increase the chance of being overweight rather than because they are morally superior, as some people say, commented the lead author. Professor Sadaf Faruki. "It's easy to hurry to judge and criticize people for their weight, but science shows that things are much more complicated, we have much less weight control than we would like to think."
"We already know that people can be thin for different reasons Some people just do not care about food while others can eat whatever they want but never get loaded If we can find the genes that prevent them from loading "We can target these genes to find new weight loss strategies and help people who do not have this advantage," says Professor Farooqi.
Previous twin studies have also shown that body weight is largely influenced by our genes. Researchers have also discovered hundreds of genes that increase the likelihood of overweight people, and in some people defective genes can cause serious obesity at an early age.