Tuesday , December 1 2020

breast cancer: Ladies, please note: Traffic-related air pollution is a risk of breast cancer



LONDON: Women working near busy roads have a high risk of developing breast cancer due to traffic-related air pollution, researchers have warned.

The team, from the University of Stirling in Scotland, analyzed the case of a woman who developed breast cancer after spending 20 years working as a border guard at the busiest commercial border crossing in North America.

The woman was one of, at least, five other border guards who developed breast cancer within 30 months of each other and, at another nearby crossing, a cluster of seven other cases was noted.

AirPollution

According to Michael Gilbertson, the findings "infer a causal relationship" between breast cancer and very high exposure to traffic-related air pollution containing mammary carcinogens. A link between night shift work and cancer was also identified.

"This new research shows the role of traffic-related air pollution contributing to the increasing incidence of breast cancer in the general population," Gilbertson said.

The group of women all developed a cancer believed to have been caused by exhaust fumes in what researchers have branded a 'new occupational disease'.

There is one in 10,000 chance cases were a coincidence, the study published in the New Solutions magazine reported, because the cancers were all similar and close together.

A review of previous research has confirmed that BRCA1 and BRCA2 genes – which can stop tumor growth – can be "silenced" by exposures to dioxins and polycyclic aromatic hydrocarbons – both found in exhaust fumes.

BRCA2 is rapidly degraded in the presence of aldehydes – also components of exhaust fumes.

"There is much more research to be done," Gilbertson said. "But we now have plausible mechanisms for inferring how BRCA1 / 2 tumor suppressors in this highly exposed border guard have become dysfunctional and likely contributing to the ongoing epidemic of sporadic early onset premenopausal breast cancer among her colleagues.

"With this new knowledge, industry and government can plan for new designs for industrial and commercial facilities to cut down on occupational exposure to traffic-related air pollution," Gilbertson said.


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