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Calgary researchers say the newly discovered cell can treat heart damage in mice



Researchers at Calgary University claim that the newly discovered cell type appears to restore heart damage in mice.

Scientists say they have found the same cell type in humans and believe it can promote new therapies for heart disease.

Researcher and cardiac surgeon Paul Fedak says he is in a fluid sack that surrounds the heart and "can hold the secret to recovery and recovery of the new heart muscle."

He says the fluid is often thrown out during surgery, but when scientists infect mice and leave the fluid intact, the mice look better than those without fluid.

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Fedak adds that the study is at a very early stage and requires further work to determine the therapeutic potential in humans.

The study was supported by the Canada Heart and Stroke Foundation, the Canadian Health Research Institutes, the Canadian Science Program, and the National Institutes of Health. The study was published today in Immunity magazine.

"This liquid that surrounds the heart does not think much about her. In fact, I suck it and throw it into the trash when I do a heart surgery, "Fedak said of the little that was known of the material that contains different cell populations, but largely consists of a cell.

"Maybe we should try to keep that intact or replace that fluid or develop new therapies to remove these cells, expand them, and then release them again in this space to improve the repair. There are many therapeutic implications of this study for the future. "

The study began with the work of Professor of Physiology and Pharmacology, Paul Kubes, who stated that he had first found similar reparative cells around the liver and intestines in 2016.

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When Cubes realized that cells helped restore these organs, he and Fedak wondered if such cells existed near the heart and lungs.

It turns out that these cells exist around many organs, says Cubes, but it is not clear how they function during a heart attack.

"One of the options is to have these cells filled in, or we need to add more of these cells to better help heal the heart," says Cubez, director of the Snyder University's Chronic Disease Institute.

Fedak says cells reduce scar formation, which in itself is a big problem.

"If a scar is formed in your heart, the scar does not work, it can not shrink or contribute to the functioning of the heart," says Fedak, the next director of the Libin Cardiovascular Institute in Alberta.

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In fact, the act of removing pericardial fluid can actually cause scarring, Fedak said, noting that he had seen scars on the outside of the heart when he had to operate with a patient who had previously been subjected to heart surgery.

– Everything is marked there. And it's probably because of the loss of that fluid and healing cells and other molecules and things that are in that fluid. "

Fedac called this study a "first step" to identify the potential of this cell, described as a macrophage of the Gata6 + pericardial cavity.

While he says studies in mice are useful as a "proof of concept", identifying applications in the real world requires moving the study to larger animal subjects such as rats, pigs and then humans.

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A possible next step will be the reintroduction of a large number of cells to see how it affects rehabilitation in mice, rats or pigs.

Cubes says the need for such research is great.

"People with a heart attack then have a limited capacity to live a normal life – walking can be a problem, just daily activity can be very tense and tiring. If we can help heal the heart more, their lives can be greatly improved. "


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