Thursday , December 3 2020

The US paper found that cannabis use had no effect on the results of kidney transplantation



People with a history of cannabis use should not be blocked by providing a living kidney gift, suggesting a new American book that finds no measurable effect on the results of kidney transplants for donors or recipients when donors have used cannabis.

The review is highlighted as the first to examine the results of donor and recipient kidney transplants when the donor has a history of marijuana use, according to a statement by Loma Linda University Health in Lomond, California.

Published on November 15, 2018 in the Journal of Clinical Kidney Journal, the results "do not show a difference in donor or symptom-based features or post-operative results based on donor marijuana use, indicating no long-term differences in kidney function among those who use marijuana and those who are not, "says retrospective medical research.

A retrospective review examines 294 entries

Researchers examined live kidney transplants carried out in an academic institution from January 2000 to May 2016, notes the article: "Should donors who have used marijuana be considered as candidates for living kidney donation?

Separating donor and recipient groups in two groups using donor cannabis, researchers examined 294 live donors of donor kidneys, including 31 donors using marijuana (MUD) and 263 non-MUD (NMUD). Overall, 230 live kidney recipes were reviewed, including 27 renal marijuana (MKC) recipients and 203 non-MRI (NMA). "

Overall, based on donor cannabis use, studies show that there is no difference in renal function between NMUD and MUD groups and there is no long-term difference in renal allograft between NMKR and MKR groups.

"Considering that people with a history of using marijuana for living kidney donors could increase the donor pool and yield acceptable results," the authors suggest.

"Living donor transplantation reduces the time the recipient spends on dialysis and increases the pulse rate of small donors," the article explains. In addition, "the results of the recipient and his graft are better when receiving a living kidney donor over the donor's dead kidney," he noted.

"Although it is quite common to smoke a pack or more cigarettes a day, even an avid marijuana user will be less likely to or even be able to consume marijuana at these levels," the article states. "Given that the time for exposure to marijuana is less, there may be less negative vascular effects than smoking marijuana, just because of this factor," he adds.

Cannabis use in steady climbing

Recipient and graft results are better for the living donor

/ iStock / Getty Images Plus

Cannabis use in the US has risen steadily over the past decade, with consumption doubled between 2001 and 2013, the university statement said. A couple with a kidney deficiency factor available for transplantation means that almost 100,000 patients were on the waiting list south of the border in 2018

With waiting up to 10 years, depending on the region and the blood group, some patients do not survive long enough for dialysis to get a transplant, the statement said.

"At the end of the renal failure stage (ESRD), patients can wait more than five years to get a kidney-donor deceased," the review reports. Noting that the distribution of the ERRD has increased by 600% from 1980 to 2009, "vital donation of kidneys has helped to increase the donor pool, there is still a great mismatch between supply and demand."

Based on the recommendations of the National Registry for Kidneys, which exclude drug abuse from the donation, the article says that "many transplant institutions refuse living kidney donors who have a history of marijuana use."

The review states that "some transplant programs adhere to the basic idea that any use of marijuana is drug abuse and will refuse to give live kidney to a person with a history of marijuana use, saying the decision is in the best interest of the donor and their "The addition of obstacles is that" most institutions do not publish specific criteria for the use of marijuana by donors, which makes it difficult to clarify how many programs donor donors who use marijuana. "

Despite this story, however, the authors argue that "there is no evidence specific to donors or recipients."

Opening life-saving access to transplants

Looking at donors using marijuana can help save lives

Regarding the significant shortage of available potential kidney donors, the review seeks "to initiate a discussion on this issue and encourage other centers on this important issue." We hope that given that donors using marijuana can end up life saving account, "says lead author Dwayne Baldwin of the Loma Linda University Health Loma Linda Department of Urology.

The report notes that the average age of living kidney donors in the United States is currently at the beginning of the mid-1930s. "Given this, over the next 10 years, the current 18- to 29-year-old population will be the largest group of living kidney donors, the same group of people currently using marijuana with a prevalence of over 21% before allowing for the next planned increase in use, "he adds.

If current trends persist in the future, "the growing population of marijuana users will become an even more significant segment of the potential live donor pool for renal donors, and then screening marijuana kidney donors may increase the donor pool," he adds. .

The dilemma of marijuana is not limited to kidney transplantation, it suggests, citing a preliminary heart transplant study that does not show differences in survival rates between cardiovascular recipients.

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