Thursday , December 3 2020

Mannose, a "miraculous" sugar that reduces the growth of the tumor

An investigation conducted in the United Kingdom concluded that a monosaccharidealso known as mannose, present in blueberries, oranges and apples may slow the growth of tumors and increases the effects of chemotherapy,

Studies are conducted on mice with multiple cancers and will need to be tested in humans, but this is a step toward understanding how mannose can be used help treat cancer, the researchers said, according to Cancer Reseach UK

Tumors use more glucose than normal and healthy tissues. However, it is very difficult to control the amount of glucose in your body with just the diet. In this study, researchers found that mannose It can affect glucose to reduce the amount of sugar cancer cells can use.

Kevin Ryan, lead author of the Beatson Cancer Institute in the United Kingdom, said: "Tumors need a lot of glucose to grow so as to limit the amount they can use slows the progression of cancer. The problem is that normal tissues also need glucose, so we can not remove it completely from the body.

"In our study, we found a dose of mannose that can block enough glucose to slow tumor growth in mice, but not as much as normal tissues are affected." This is an initial study, but we hope that finding this perfect balance means, in the future, can be administration of mannose in cancer patients to improve chemotherapy without harming your overall health. "

Researchers first investigate how mice respond with pancreatic, lung or skin cancer when added mannose to drinking water and is administered as an oral treatment. They found that addition of the additive significantly reduced tumor growth and did not produce any obvious side effects.

To investigate how mannose can also influence cancer treatment, mice are treated with cisplatin and doxorubicin, two of the most commonly used chemotherapeutic agents. They found that mannose improves the effects of chemotherapy, reduces tumor growth, diminishes the size of tumors, and even increases the life expectancy of some mice.

Other types of cancer, such as leukemia, osteosarcoma, ovarian and intestinal cancer, have been studied. Researchers cultivate cancer cells in the lab and then treat themselves with mannose to see if their growth is affected.

Some cells responded well to the treatment and others did not. It was also found that the presence of an enzyme that degrades mannose in the cells this is a good indicator of the effectiveness of treatment.

Professor Kevin Ryan added, "Our next step is to investigate why treatment only works in some cells to determine which patients could benefit most from this approach." We hope that we can initiate clinical man- people to identify their real potential as new cancer therapy ".

Mannose is sometimes used for short periods of time to treat urinary tract infections, but its long-term effects have not been studied. More research is important before mannose can be used in cancer patients.

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