In a study of mice, the researchers found that their strongest peptide could completely eliminate Pseudomonas aeruginosa, a strain of bacteria that causes respiratory and other infections and resistant to most antibiotics.
In a mouse study, researchers have found this its strongest peptide can completely eliminate Pseudomonas aeruginosa, a strain of bacteria that causes respiratory and other infections and is resistant to most antibiotics.
"We have used a re-toxic molecule in one that is a viable molecule to treat infections," he says. Caesar de la Fuente-Nunes, one of the authors of the article published in the magazine Biology of natural communications, "By systematically analyzing the structure and function of these peptides, we have succeeded in correcting their properties and activity," he continues.
Poisoning insects such as bees and bees is full of compounds that can kill bacteria but which are also toxic to humans. In order to help fight the emergence of antibiotic-resistant bacteria, many scientists are trying adapt these peptides as new potential drugs,
The peptide de la Fuente-Nuñez and his colleagues focused on this study was isolated from the orb, known as Polybia paulistaThe team chose the most promising test compound in mice infected with Pseudomonas aeruginosa, a common source of respiratory and urinary tract infections, and found that several of the peptides could reduce the infection. One of these, given with a high dose, can remove it completely.
"After four days, this compound can completely eliminate the infection, and that was quite surprising and exciting because we usually do not see this with other experimental antimicrobials or other antibiotics that we have tried in the past with this particular mouse model, "says De la Fuente Núñez.