Scientists at the University of Oxford have studied Mexican fish, capable of regenerating their own heart and discovered that a gene that makes it possible to have exceptional human capacityThe results of the new study, published in the journal Cell Reports, give hope for positive changes in the lives of patients who have had heart attacks, the researchers said.
To come to this conclusion, the team of scientists led by Professor Matilda Mommergge studied two types of tetra Mexican fish. on Astyanax mexicanus, who lives in rivers and she shows a beautiful color, can heal her own heart while the second subtype, which populate the waters of the cave of Pachón and is known as "blind tetra"not only has he lost his color and vision, characteristics that do not serve him in the darkness of the cave, but he no longer has the ability to regenerate the tissue of the heart.
In the study, the researchers They compare the genetic profiles of the two types of teats and identified three areas in their genomes that are related to the possibility of regenerating damaged heart tissue.
Then, after comparing the behavior of these genes in the Tetra River and in the tetrava, blinded after cardiac damage, scientists found that only the first two had the activity of both genes. lrrc10 (also available in humans) and caveline,
Previous studies of mice meanwhile also indicate that lrrc10 is associated with a cardiac condition called extended cardiomyopathy, where the heart becomes excessively enlarged and can not pump the blood properly. The results of the following studies suggest that lrrc10 plays a key role in the contraction and expansion of heart cells,
To confirm that this gene is also involved in the regeneration of damaged heart tissue, researchers in the new study have turned to zebrafish, another type of fresh water that, like tetrava fish, also has the ability to regenerate heart tissue. if necessary. Scientists blocked the expression of the lrrc10 gene in zebrafish, making them unable to effectively repair heart damage.
In the future, the research team hopes to learn more about mechanisms of recovery of this tissue and to use this knowledge in people who have problems with this body, such as heart failure.