A research team from the University of California, UCLA, has developed a biodegradable spray gel with medications that improve the immune system in their experiments have prevented the reproduction of cancer in laboratory animals and prevent its spreading to other parts of the body.
The aerosol not only prevents the recovery of tumors in the area of the body from which they are extracted, but also "controls the development of tumors in other parts of the body," according to the research director, professor of bioengineering at the UCLA Institute of Engineering, Samuel and a member of Johnson University at the same university, Zhen Gu.
The survey has shown that many people who are diagnosed with cancer will undergo some kind of surgery to treat your illness, Almost 95% of patients with breast cancer An early diagnosis will require surgery and, in general, this is the first treatment line for people with brain tumors. But "despite the improvements in surgical techniques of the last decade, cancer often returns after the procedure," warns UCLA.
Researchers they tested the gel in mice that had advanced tumors of the melanoma removed surgically when administered, the growth of tumor cells remaining after the surgery decreases, which helps to prevent recurrence of cancer. Upon receiving the treatment, 50% of the mice survive at least 60 days without the tumors recovering.
Around 90% of people with cancerous tumors eventually dying due to tumor recurrence or metastasis, explain from UCLA. Therefore, Gu says, "This spray gel is promising against one of the biggest obstacles to curing cancer."
Researchers are loading nanoparticles with an antibody directed specifically to block CD47, a protein that releases cancer cells. By blocking CD47, the antibody allows the immune system to find and finally destroy the cancer cells.
The nanoparticles are made of calcium carbonate, which can dissolve gradually in the sites of the surgical wounds and increase the activity of a type of macrophage that "helps to dispose of foreign objects from the body," according to Gu's laboratory postdoctoral researcher and lead author of the study, Qian Chen,
It was also noted that the gel can activate T-cells in the immune system to work together as another line of attack against persistent cancer cells, Chen explains. This substance will need to go through more tests and approvals before it can to be used in humans they report from UCLA.
With information from Europa Press