A group of researchers from the Massachusetts Institute of Technology have created an insulin pill for diabetics, which can replace daily injections in patients.
After years of efforts by the medical community to develop a less invasive and more practical method of delivering insulin to diabetic patients, a MIT research group came out with their nails: they created a capsule that could be used for oral administration of the hormone.
How it works?
The new study published in the magazine sciencenotes that a blueberry pill made of biodegradable polymers and stainless steel components will release insulin into the stomachs of humans, which could replace daily injections in patients with type 2 diabetes as it contains a small needle made of compressed insulin that is injected after the fat reaches the stomach.
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(Photo: La Jornada)
MIT scientists have explained that when the needle tip is injected into the stomach wall, insulin dissolves at a controlled rate. This study takes about an hour to free all medications in the bloodstream.
During animal studies, scientists have demonstrated that enough drugs can be given to lower blood sugar to levels comparable to those generated by the injection through the skin. The results also indicate that the device may be adapted for administration of other protein drugs.
Specialists successfully demonstrated the administration of up to 300 micrograms of insulin. However, they are able to increase the dose to five milligrams, a dose comparable to the amount injected by a patient with type 2 diabetes.
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During the tests no side effects were found when using the capsule, which can pass smoothly through the digestive system.
"We very much hope that this type of capsule will someday help diabetic patients and perhaps anyone who requires treatments that can now be given only by injection or infusion," said Robert Langer, one of the lead authors of the study.
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