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A new study suggests that a drug, a non-steroidal anti-inflammatory drug (NSAID), that helps control pain and inflammation in people with osteoarthritis (OA), can lead to cardiovascular disease.
The study published in the journal Arthritis and rheumatology, matched 7,743 OA patients with 23,219 non-OA controls. The risk of developing cardiovascular disease in people with OA is 23% higher than in people without OA.
Among the secondary outcomes evaluated in the study, the risk of congestive heart failure is 42% higher among people with OA compared with people without OA, followed by a 17 percent higher risk of ischemic heart disease and 14 percent more. high risk of stroke,
Investigators find that approximately 41 percent of the increased risk of cardiovascular disease in people with OA is mediated through their use of NSAIDs. NSAIDs also play a significant role in the development of secondary research results.
"To our knowledge, this is the first longitudinal study to evaluate the mediating role of NSAID use in the relationship between osteoarthritis and cardiovascular disease in a large population-based sample. Our results show that osteoarthritis is an independent risk factor for cardiovascular disease and suggest that a significant portion of the increased risk is due to the use of NSAIDs, "says Aslam Anis, senior author of the study
"This is very relevant as NSAIDs are some of the most commonly used pain management medications in patients with osteoarthritis. It's important for people with OA to talk to their care providers and discuss the risks and benefits of NSAIDs, "Anis added.
Posted: August 9, 2019 11:28 AM
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