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The world's first insulin technology to provide better diabetes care


The world's first insulin technology to provide better diabetes care

Prominent Professor Jeff Chase is working on the world's first insulin sensor technology for those who manage type 2 diabetes. Credit: University of Canterbury

Prominent professor Jeff Chase of the College of Engineering at the University of Canterbury (UK) is working on the world's first insulin sensor technology to enable "on-the-go" measurement for those managing type 2 diabetes.

The development of insulin measurement technology will allow doctors and patients to make better informed treatment decisions immediately, says Professor Chase. People can find their blood sugar levels from the well-known rod and glucose test, but insulin can currently only be measured in a laboratory.

"What makes it difficult to test Point-of-Care insulin is that it has no known chemical reaction to test. Unlike glucose, insulin has no polarized charge, does not carry voltage, or responds to magnetic fields, radio frequency or microwaves." That way, it's kind of a "stealth" molecule in terms of facilitating detection, he says.

The Honorable Professor Chase works with the Director of the Center for Biomolecular Interaction of UC Dr. Volker Knock and PhD Dr. Rebecca Soph from Senior Lecturer in Electrical and Computer Engineering and Mechanical Engineering Dr. Stephanie Gutschmid to develop the Lab-on technology -Chip using microfluidics, specialized bioreceptors and a new micro-electro-mechanical system (MEMS) technology that models for the detection of insulin in a liquid sample.

"The fixed volume of fluid will adhere to the microchip, allowing the rest to leak. This changes the mass and thickness of the MEMS array elements, which in turn allows us to" see "that mass of insulin as it changes dynamic properties. of MEMS arrays. Anyway, we hope with the patent that has been filed. "

Funding for the National Science Challenge: The Science of Technological Innovation, Finding a Key Measurement of Insulin at the Point of Care is part of a suite of technologies developed to manage type 2 diabetes.

Currently, measuring insulin requires laboratory processing of a blood sample, which takes 1-3 days for the result. The process and delay makes the test useful only for the initial diagnosis of type 2 diabetes without managing long-term care.

"When you do not know your insulin levels, you have to guess. Patients tend to get into trouble and will often refuse treatment because the risk of injecting too much insulin is too high," says Professor Chase. "With this sensor, you can know what your insulin level is and can safely dose it, reducing this risk."

The renowned Professor Chase has 19 years of experience working with doctors. His areas of study include diabetes, modeling of human metabolism and hypoglycemia, and he enjoys seeing the impact of his work in the real world. In 2018 he was awarded the MacDiarmid Medal by the Royal Society of Te Apārangi for the physiological modeling of human metabolism used for in-silico testing, which is used to treat intensive care patients in New Zealand and abroad.

"I like the opportunity to see the work I do as a whole have an impact. The ultimate recognition is to see how something is perceived and to see the science applied to the benefit of man."

One third of type 1 diabetes has been misdiagnosed in the 1930s

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University of Canterbury

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