Alzheimer's is a devastating neurodegenerative disorder that has plagued the brain and has never been cured. There are only treatments to control or delay the symptoms. However, scientists at the University of Buffalo (New York, USA) have discovered a new approach to treatment, which one day could reverse the memory loss.
The study, published Tuesday in Brain Journal, focuses on the study of epigenetics, which explores changes in the expression of genes that are not susceptible to DNA sequence alteration.
These epigenetic changes, characteristic of the disease, occur mainly when patients can not keep the information they have learned recently and have a significant cognitive decline. Scientists claim that the main reason for this deterioration is the loss of glutamate receptors, which are critical to learning and short-term memory"said Jen Jan, head of the study.
– An epigenetic approach can correct the genetic network Collectively, it will restore the cells to their normal state and fill the complex brain function, says Yan.
The study was not only responsible for identifying these factors but also found ways to do so temporarily turn them overTo this end, the team of scientists uses mice bearing genetic mutations for the Alzheimer family (where more than one family member suffers from the disease) injected with compounds designed to suppress the enzyme that controls the genetic modification. After receiving a solution, they showed surprising changes in memory recognition, spatial memory, and working memory.
Although improvements took just one week, researchers are working to improve the administration method so that it has a stronger effect, according to the EFE agency.
In any case, it is reported that these results do not guarantee that the same effects may occur when applied to humans or even to other Alzheimer's.