Wednesday , July 28 2021

The vaccine may delay the onset of Alzheimer's disease



A team of American researchers has been able to prevent the accumulation in the brain of toxic proteins that cause Alzheimer's disease. Tests have been conducted so far on laboratory mice but can be tested on humans, according to RTE. The new vaccine contains DNA encoding a segment of the beta-amyloid protein building block. In the study, the vaccine triggered an immune response that not only resulted in a 40% decrease in β-amyloid formation but also reduced protein production by 50%. The study was conducted on mice that were genetically engineered to develop the influenza equivalent of Alzheimer's disease, says adevarul.ro.

"This study is the result of a decade-long research that has repeatedly demonstrated that this vaccine can reliably and reliably identify by animal models what we think may cause Alzheimer's disease," said Dr. Roger Rosenberg, director of the research team, director of the Center for Alzheimer's Disease, University of Texas, quoted by agerpres.ro. "I think we are getting closer to testing this therapy for people," he said. A major obstacle to the development of effective anti-Alzheimer's vaccines is to find ways to introduce them into the body.

The earlier experimental vaccine, developed in the early 2000s, caused some brain tumors in some patients when tested on humans. The new vaccine is injected into the skin instead of into the muscle, resulting in another type of immune response. If the effects seen in mice will be repeated in humans, this vaccine will have "great therapeutic value," the researchers said. "If the onset of the disease can be postponed for five years, it would be immense for patients and their families," said researcher Doris Lambrakcht-Washington, another member of the University of Texas team, "The number of cases of dementia may half falls, "he said. A number of drugs targeting cerebral amyloid protein retain and develop or are clinically tested. But an effective vaccine will be a better strategy, according to researchers from the University of Texas. It would be more affordable and cheaper. Earlier this year, the same team of researchers found the exact point where the molecule became harmful but has not yet formed "crowds" in the brain.

Scientists are also working on a spinal fluid test that can detect your abnormal protein before the onset of symptoms of the disease. Such a test can identify people who do not yet have symptoms but have high levels of tau and amyloid in the brain. Patients identified by this test may be candidates for treatment with the vaccine. – The longer you wait, the less will it be. Once these boards and clones have been formed, it may be too late, "Dr. Rosenberg explained." The results of the study have been published in Alzheimer's research and therapy. "It is common knowledge that two types of toxic proteins play a key role in the development of Alzheimer's disease – beta-amyloid and yours Beta-amyloid and your brain accumulate in the brain and cause the destruction of nerve cells Some studies have shown that both types are linked, beta-amyloid, favoring the formation of "agglomerations" caused by Your pro in.


Source link