Tuesday , October 26 2021

high doses of Vitamin D improve metabolism



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Science continues to discover the valuable properties of Vitamin D. This time researchers at Laval University in Quebec, Canada, found that taking high doses of 'sunshine' vitamin slows down the progression of diabetes. Apparently that's the case Vitamin D has a beneficial effect on glucose metabolism in the body, that is, the processes of its breakdown and assimilation, scientists suggest. At the same time, there is an important caveat: taking shock doses only helps and inhibits the development of diabetes in its initial stages. It can also help prevent illness for those diagnosed with prediabetes.

This was already known Vitamin D deficiency increases the risk of diabetes. However, there is no definitive evidence that supplementation with vitamins may prevent the onset and progression of the disease. The new study involved patients with recently started type 2 diabetes or pre-diabetes. For 6 months, volunteers receive a dose of vitamin D 5 to 10 times the normal dose (see below). However, only 46% of patients initially had low levels of vitamin A while others did not suffer from a deficiency.

The researchers measured the main indicators of metabolism (metabolism) in our body: glucose and hormone insulin levels. By the end of the experiment, these parameters had improved significantly, scientists say. Most importantly, muscle insulin sensitivity has increased.

"Unfortunately, no such improvements have been noted before by our colleagues who conducted similar studies with people in the later stages of diabetes," says one of the authors of the research, Dr. Claudia Gagnon. However, this does not mean that vitamin D does not have a positive effect on patients with advanced diabetes. Changes are likely, but due to complications of the disease, the improvements are not so noticeable. Or you need even higher doses of vitamin A and longer intake, Dr. Gagan suggested.


Vitamin D deficiency increases the risk of diabetes. Photo: EASTERN NEWS

Vitamin D deficiency increases the risk of diabetes.View: EASTERN NEWS

At the same time, the researchers stress that their experiment should never be repeated on its own. Only the doctor can determine the need and dose of the vitamin. Moreover, studies continue, as there is no data yet on how long-term high doses of vitamin D. can affect the body. And what dose would be optimal in one case.

NOTE

Norm or deficit?

Today, doctors evaluate the level of vitamin D in the blood as follows:

– 30-60 ng / ml is considered optimal;

– less than 30 ng / ml – deficiency when it is already necessary to prescribe a therapeutic dose of vitamin A;

– less than 20 ng / ml – deficiency in which associated diseases may develop.

How about blood sugar levels?

– 3.3 – 5.5 mmol / l – normal;

– from 6 to 6.7 mmol / l – prediabetes;

– 6,7 mmol / l and above – diabetes.

COMMENTARY DOCTOR

Everyone needs this vitamin in normal amounts, like any vital substance.

Recent scientific and medical data have asked us to talk about the role of vitamin D and its effect on the body. Zuhra Pavlov, an endocrinologist at the University Clinic of Moscow State University, scientific director of the Clinic of Systemic Medicine, Candidate of Medical Sciences, the leading Internet channel "Notes by Dr. Pavlova."

Vitamin D is the precursor to D-hormone, the most important substance in our body. Depending on the place of residence, a person may be deprived of the full production of this substance in the body.

For example, residents of the northern latitudes, where there is little sun, often suffer from deficits. Or people who eat little vitamin D foods (eggs, butter, sea fish and p, – Ed.). It is now also known that there are polymorphisms – innate changes, variants of genes in which a person has Vitamin D simply cannot be produced in the required amount, even under favorable external conditions.

How Much Should I Take Vitamin D? The existing official recommendations are very old. For example, according to World Health Organization norms, the daily dose is 400-500 International Units (IU). But I know from my own experience: it does not cover the chronic deficit we are all in. Most often, after all tests, I should prescribe at least 5000 IU a day. I know foreign colleagues who have the same experience.

The study noted that increased doses of vitamin A led to an improvement. Here's how to get the metabolic response you need, that is, improvements, including clinical ones.

I emphasize that you do not need to be "treated by the Internet", your doctor, such as an endocrinologist, should determine the deficiency and dose separately.

Because vitamin D is a precursor to the hormone, it acts systemically on the body. Vitamin deficiency impairs cognitive functions such as memory. Bone mineral density decreases. And when the hormone level rises to normal levels, even the production of sex hormone testosterone in men improves.

It is important not to lead to a chronic deficiency of vitamin D. As the longer the disorder lasts, the more severe the complications develop. Running them down to their original level usually fails. The earlier the deficits of all substances, including vitamin D, are filled up, the better.

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