Wednesday , December 2 2020

Changes in vascular cells can help in early detection



Washington, DC

A new study shows that atherosclerosis can be detected by signs that contribute to knowledge of arterial blockage, by looking at how cells change in their blood vessels, according to the latest findings, published in the November issue of Nature Telecommunications).

The magazine notes that it has long been known that neurons lining blood vessels are multi-tasking, while their main function is pumping blood throughout the body, they also participate in injuries, "playing" in blood vessels … And can cause excessive DNA switching to hardened cells, leading to the formation of "plaques" in blood vessels that block the flow of blood.

Using modern genome techniques, a multidisciplinary research team in Cambridge and London captured a small number of vascular muscle cells in rat blood vessels in the switching process and described their molecular properties. The researchers used innovative methodologies known as single cell RNA sequences, Activities mostly genes in the genome are tracked in hundreds of individual vascular muscle cells.

The researchers believe that this study can open the way to detect "switched" cells in humans, allowing the diagnosis and treatment of atherosclerosis at a very early stage in the future.

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